Calculate interval AUC

It calculates interval AUC

IntAUC(x, y, t1, t2, Res, down = "Linear")

Arguments

x

vector values of independent variable, usually time

y

vector values of dependent variable, usually concentration

t1

start time for AUC

t2

end time for AUC

Res

result from sNCA function

down

either of "Linear" or "Log" to indicate the way to calculate AUC

Details

This calculates an interval (partial) AUC (from t1 to t2) with the given series of x and y. If t1 and/or t2 cannot be found within x vector, it interpolates according to the down option.

Value

return interval AUC value (scalar)

References

1. Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

2. Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.

3. Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.

4. Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.

Author

Kyun-Seop Bae <k@acr.kr>

See also

AUC, Interpol

Examples

Res = sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], 
           dose=320, concUnit="mg/L")
IntAUC(Theoph[Theoph$Subject==1, "Time"], Theoph[Theoph$Subject==1, "conc"], t1=0.5, t2=11, Res)
#> [1] 84.08191