Simplest NCA

This is the work-horse function for NCA.

sNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
     concUnit = "ug/L", iAUC = "", down = "Linear", R2ADJ = 0.7, MW = 0, Keystring="",
     excludeDelta = 1)

Arguments

x

usually time

y

usually concentration

dose

given amount, not amount per body weight

adm

one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode

dur

duration of infusion

doseUnit

unit of dose

timeUnit

unit of time

concUnit

unit of concentration

iAUC

interval AUCs to calculate

down

either of "Linear" or "Log" to indicate the way to calculate AUC and AUMC

R2ADJ

Minimum adjusted R-square value to determine terminal slope automatically

MW

molecular weight of the drug

Keystring

a text string to be shown at the plot in case of manual selection of terminal slope

excludeDelta

Improvement of R2ADJ larger than this value could exclude the last point. Default value 1 is for the compatibility with other software.

Details

This replaced previous IndiNCA. Author recommends to use excludeDelta option with about 0.3.

Value

CMAX

maximum concentration, Cmax

CMAXD

dose normalized Cmax, CMAX / Dose, Cmax / Dose

TMAX

time of maximum concentration, Tmax

TLAG

time to observe the first non-zero concentration, for extravascular administration only

CLST

last positive concentration observed, Clast

CLSTP

last positive concentration predicted, Clast_pred

TLST

time of last positive concentration, Tlast

LAMZHL

half-life by lambda z, ln(2)/LAMZ

LAMZ

lambda_z negative of the best-fit terminal slope

LAMZLL

earliest time for LAMZ

LAMZUL

last time for LAMZ

LAMZNPT

number of points for LAMZ

CORRXY

correlation of log(concentration) and time

R2

R-squared

R2ADJ

R-squared adjusted

C0

back extrapolated concentration at time 0, for intravascular bolus administration only

AUCLST

AUC from 0 to TLST

AUCALL

AUC using all the given points, including trailing zero concentrations

AUCIFO

AUC infinity observed

AUCIFOD

AUCIFO / Dose

AUCIFP

AUC infinity predicted using CLSTP instead of CLST

AUCIFPD

AUCIFP / Dose

AUCPEO

AUC % extrapolation observed

AUCPEP

AUC % extrapolated for AUCIFP

AUCPBEO

AUC % back extrapolation observed, for bolus IV administration only

AUCPBEP

AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only

AUMCLST

AUMC to the TLST

AUMCIFO

AUMC infinity observed using CLST

AUMCIFP

AUMC infinity determined by CLSTP

AUMCPEO

AUMC % extrapolated observed

AUMCPEP

AUMC % extrapolated predicted

MRTIVLST

mean residence time (MRT) to TLST, for intravascular administration

MRTIVIFO

mean residence time (MRT) infinity using CLST, for intravascular administration

MRTIVIFP

mean residence time (MRT) infinity using CLSTP, for intravascular administration

MRTEVLST

mean residence time (MRT) to TLST, for extravascular administration

MRTEVIFO

mean residence time (MRT) infinity using CLST, for extravascular administration

MRTEVIFP

mean residence time (MRT) infinity using CLSTP, for extravascular administration

VZO

volume of distribution determined by LAMZ and AUCIFO, for intravascular administration

VZP

volume of distribution determined by LAMZ and AUCIFP, for intravascular administration

VZFO

VZO for extravascular administration, VZO/F, F is bioavailability

VZFP

VZP for extravascular administration, VZP/F, F is bioavailability

CLO

clearance using AUCIFO, for intravascular administration

CLP

clearance using AUCIFP, for intravascular administration

CLFO

CLO for extravascular administration, CLO/F, F is bioavailability

CLFP

CLP for extravascular administration, CLP/F, F is bioavailability

VSSO

volume of distribution at steady state using CLST, for intravascular administration only

VSSP

volume of distribution at steady state using CLSTP, for intravascular administration only

References

Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

Author

Kyun-Seop Bae <k@acr.kr>

See also

help, tblNCA

Examples

# For one subject
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]

sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")
#>           b0         CMAX        CMAXD         TMAX         TLAG         CLST 
#>    2.3687851   10.5000000    0.0328125    1.1200000    0.0000000    3.2800000 
#>        CLSTP         TLST       LAMZHL         LAMZ       LAMZLL       LAMZUL 
#>    3.2801465   24.3700000   14.3043776    0.0484570    9.0500000   24.3700000 
#>      LAMZNPT       CORRXY           R2        R2ADJ       AUCLST       AUCALL 
#>    3.0000000   -0.9999999    0.9999997    0.9999995  148.9230500  148.9230500 
#>       AUCIFO      AUCIFOD       AUCIFP      AUCIFPD       AUCPEO       AUCPEP 
#>  216.6119330    0.6769123  216.6149558    0.6769217   31.2489169   31.2498763 
#>      AUMCLST      AUMCIFO      AUMCIFP      AUMCPEO      AUMCPEP         VZFO 
#> 1459.0711035 4505.5348194 4505.6708646   67.6160287   67.6170065   30.4867482 
#>         VZFP         CLFO         CLFP     MRTEVLST     MRTEVIFO     MRTEVIFP 
#>   30.4863228    1.4772963    1.4772757    9.7974834   20.8000305   20.8003683 
#> attr(,"units")
#>  [1] ""          "mg/L"      "mg/L/mg"   "h"         "h"         "mg/L"     
#>  [7] "mg/L"      "h"         "h"         "/h"        "h"         "h"        
#> [13] ""          ""          ""          ""          "h*mg/L"    "h*mg/L"   
#> [19] "h*mg/L"    "h*mg/L/mg" "h*mg/L"    "h*mg/L/mg" "%"         "%"        
#> [25] "h2*mg/L"   "h2*mg/L"   "h2*mg/L"   "%"         "%"         "L"        
#> [31] "L"         "L/h"       "L/h"       "h"         "h"         "h"        
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x, y, dose=320, concUnit="mg/L")
#>           b0         CMAX        CMAXD         TMAX         TLAG         CLST 
#>    2.3687851   10.5000000    0.0328125    1.1200000    0.0000000    3.2800000 
#>        CLSTP         TLST       LAMZHL         LAMZ       LAMZLL       LAMZUL 
#>    3.2801465   24.3700000   14.3043776    0.0484570    9.0500000   24.3700000 
#>      LAMZNPT       CORRXY           R2        R2ADJ       AUCLST       AUCALL 
#>    3.0000000   -0.9999999    0.9999997    0.9999995  148.9230500  148.9230500 
#>       AUCIFO      AUCIFOD       AUCIFP      AUCIFPD       AUCPEO       AUCPEP 
#>  216.6119330    0.6769123  216.6149558    0.6769217   31.2489169   31.2498763 
#>      AUMCLST      AUMCIFO      AUMCIFP      AUMCPEO      AUMCPEP         VZFO 
#> 1459.0711035 4505.5348194 4505.6708646   67.6160287   67.6170065   30.4867482 
#>         VZFP         CLFO         CLFP     MRTEVLST     MRTEVIFO     MRTEVIFP 
#>   30.4863228    1.4772963    1.4772757    9.7974834   20.8000305   20.8003683 
#> attr(,"units")
#>  [1] ""          "mg/L"      "mg/L/mg"   "h"         "h"         "mg/L"     
#>  [7] "mg/L"      "h"         "h"         "/h"        "h"         "h"        
#> [13] ""          ""          ""          ""          "h*mg/L"    "h*mg/L"   
#> [19] "h*mg/L"    "h*mg/L/mg" "h*mg/L"    "h*mg/L/mg" "%"         "%"        
#> [25] "h2*mg/L"   "h2*mg/L"   "h2*mg/L"   "%"         "%"         "L"        
#> [31] "L"         "L/h"       "L/h"       "h"         "h"         "h"        
#> attr(,"UsedPoints")
#> [1]  9 10 11

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)
#>           b0         CMAX        CMAXD         TMAX         TLAG         CLST 
#>    2.3687851   10.5000000    0.0328125    1.1200000    0.0000000    3.2800000 
#>        CLSTP         TLST       LAMZHL         LAMZ       LAMZLL       LAMZUL 
#>    3.2801465   24.3700000   14.3043776    0.0484570    9.0500000   24.3700000 
#>      LAMZNPT       CORRXY           R2        R2ADJ       AUCLST       AUCALL 
#>    3.0000000   -0.9999999    0.9999997    0.9999995  148.9230500  148.9230500 
#>       AUCIFO      AUCIFOD       AUCIFP      AUCIFPD       AUCPEO       AUCPEP 
#>  216.6119330    0.6769123  216.6149558    0.6769217   31.2489169   31.2498763 
#>      AUMCLST      AUMCIFO      AUMCIFP      AUMCPEO      AUMCPEP         VZFO 
#> 1459.0711035 4505.5348194 4505.6708646   67.6160287   67.6170065   30.4867482 
#>         VZFP         CLFO         CLFP     MRTEVLST     MRTEVIFO     MRTEVIFP 
#>   30.4863228    1.4772963    1.4772757    9.7974834   20.8000305   20.8003683 
#>   AUC[0-12h]   AUC[0-24h] 
#>   91.7355220  147.6945866 
#> attr(,"units")
#>  [1] ""          "mg/L"      "mg/L/mg"   "h"         "h"         "mg/L"     
#>  [7] "mg/L"      "h"         "h"         "/h"        "h"         "h"        
#> [13] ""          ""          ""          ""          "h*mg/L"    "h*mg/L"   
#> [19] "h*mg/L"    "h*mg/L/mg" "h*mg/L"    "h*mg/L/mg" "%"         "%"        
#> [25] "h2*mg/L"   "h2*mg/L"   "h2*mg/L"   "%"         "%"         "L"        
#> [31] "L"         "L/h"       "L/h"       "h"         "h"         "h"        
#> [37] "h*mg/L"    "h*mg/L"   
#> attr(,"UsedPoints")
#> [1]  9 10 11

MW = 180.164 # Molecular weight of theophylline

sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h")
#> Warning: Molecular weight should be given for more informative results!
#>            b0          CMAX         CMAXD          TMAX          TLAG 
#> -2.8250824530  0.0582802336  0.0001821257  1.1200000000  0.0000000000 
#>          CLST         CLSTP          TLST        LAMZHL          LAMZ 
#>  0.0182056349  0.0182064479 24.3700000000 14.3043775711  0.0484569970 
#>        LAMZLL        LAMZUL       LAMZNPT        CORRXY            R2 
#>  9.0500000000 24.3700000000  3.0000000000 -0.9999998648  0.9999997297 
#>         R2ADJ        AUCLST        AUCALL        AUCIFO       AUCIFOD 
#>  0.9999994593  0.8265971559  0.8265971559  1.2023041953  0.0037572006 
#>        AUCIFP       AUCIFPD        AUCPEO        AUCPEP       AUMCLST 
#>  1.2023209731  0.0037572530 31.2489169405 31.2498763313  8.0985718762 
#>       AUMCIFO       AUMCIFP       AUMCPEO       AUMCPEP          VZFO 
#> 25.0079639629 25.0087190814 67.6160286851 67.6170064935            NA 
#>          VZFP          CLFO          CLFP      MRTEVLST      MRTEVIFO 
#>            NA            NA            NA  9.7974833547 20.8000305256 
#>      MRTEVIFP 
#> 20.8003683211 
#> attr(,"units")
#>  [1] ""            "mmol/L"      "mmol/L/mg"   "h"           "h"          
#>  [6] "mmol/L"      "mmol/L"      "h"           "h"           "/h"         
#> [11] "h"           "h"           ""            ""            ""           
#> [16] ""            "h*mmol/L"    "h*mmol/L"    "h*mmol/L"    "h*mmol/L/mg"
#> [21] "h*mmol/L"    "h*mmol/L/mg" "%"           "%"           "h2*mmol/L"  
#> [26] "h2*mmol/L"   "h2*mmol/L"   "%"           "%"           "L"          
#> [31] "L"           "L/h"         "L/h"         "h"           "h"          
#> [36] "h"          
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h", MW=MW)
#>            b0          CMAX         CMAXD          TMAX          TLAG 
#> -2.8250824530  0.0582802336  0.0001821257  1.1200000000  0.0000000000 
#>          CLST         CLSTP          TLST        LAMZHL          LAMZ 
#>  0.0182056349  0.0182064479 24.3700000000 14.3043775711  0.0484569970 
#>        LAMZLL        LAMZUL       LAMZNPT        CORRXY            R2 
#>  9.0500000000 24.3700000000  3.0000000000 -0.9999998648  0.9999997297 
#>         R2ADJ        AUCLST        AUCALL        AUCIFO       AUCIFOD 
#>  0.9999994593  0.8265971559  0.8265971559  1.2023041953  0.0037572006 
#>        AUCIFP       AUCIFPD        AUCPEO        AUCPEP       AUMCLST 
#>  1.2023209731  0.0037572530 31.2489169405 31.2498763313  8.0985718762 
#>       AUMCIFO       AUMCIFP       AUMCPEO       AUMCPEP          VZFO 
#> 25.0079639629 25.0087190814 67.6160286851 67.6170064935 30.4867482346 
#>          VZFP          CLFO          CLFP      MRTEVLST      MRTEVIFO 
#> 30.4863228055  1.4772962667  1.4772756517  9.7974833547 20.8000305256 
#>      MRTEVIFP 
#> 20.8003683211 
#> attr(,"units")
#>  [1] ""            "mmol/L"      "mmol/L/mg"   "h"           "h"          
#>  [6] "mmol/L"      "mmol/L"      "h"           "h"           "/h"         
#> [11] "h"           "h"           ""            ""            ""           
#> [16] ""            "h*mmol/L"    "h*mmol/L"    "h*mmol/L"    "h*mmol/L/mg"
#> [21] "h*mmol/L"    "h*mmol/L/mg" "%"           "%"           "h2*mmol/L"  
#> [26] "h2*mmol/L"   "h2*mmol/L"   "%"           "%"           "L"          
#> [31] "L"           "L/h"         "L/h"         "h"           "h"          
#> [36] "h"          
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x, y, dose=320/MW, doseUnit="mmol", concUnit="mg/L", timeUnit="h", MW=MW)
#>           b0         CMAX        CMAXD         TMAX         TLAG         CLST 
#>    2.3687851   10.5000000    5.9116312    1.1200000    0.0000000    3.2800000 
#>        CLSTP         TLST       LAMZHL         LAMZ       LAMZLL       LAMZUL 
#>    3.2801465   24.3700000   14.3043776    0.0484570    9.0500000   24.3700000 
#>      LAMZNPT       CORRXY           R2        R2ADJ       AUCLST       AUCALL 
#>    3.0000000   -0.9999999    0.9999997    0.9999995  148.9230500  148.9230500 
#>       AUCIFO      AUCIFOD       AUCIFP      AUCIFPD       AUCPEO       AUCPEP 
#>  216.6119330  121.9552259  216.6149558  121.9569278   31.2489169   31.2498763 
#>      AUMCLST      AUMCIFO      AUMCIFP      AUMCPEO      AUMCPEP         VZFO 
#> 1459.0711035 4505.5348194 4505.6708646   67.6160287   67.6170065   30.4867482 
#>         VZFP         CLFO         CLFP     MRTEVLST     MRTEVIFO     MRTEVIFP 
#>   30.4863228    1.4772963    1.4772757    9.7974834   20.8000305   20.8003683 
#> attr(,"units")
#>  [1] ""            "mg/L"        "mg/L/mmol"   "h"           "h"          
#>  [6] "mg/L"        "mg/L"        "h"           "h"           "/h"         
#> [11] "h"           "h"           ""            ""            ""           
#> [16] ""            "h*mg/L"      "h*mg/L"      "h*mg/L"      "h*mg/L/mmol"
#> [21] "h*mg/L"      "h*mg/L/mmol" "%"           "%"           "h2*mg/L"    
#> [26] "h2*mg/L"     "h2*mg/L"     "%"           "%"           "L"          
#> [31] "L"           "L/h"         "L/h"         "h"           "h"          
#> [36] "h"          
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
#>          b0        CMAX       CMAXD        TMAX        TLAG        CLST 
#> -2.82508245  0.05828023  0.03281250  1.12000000  0.00000000  0.01820563 
#>       CLSTP        TLST      LAMZHL        LAMZ      LAMZLL      LAMZUL 
#>  0.01820645 24.37000000 14.30437757  0.04845700  9.05000000 24.37000000 
#>     LAMZNPT      CORRXY          R2       R2ADJ      AUCLST      AUCALL 
#>  3.00000000 -0.99999986  0.99999973  0.99999946  0.82659716  0.82659716 
#>      AUCIFO     AUCIFOD      AUCIFP     AUCIFPD      AUCPEO      AUCPEP 
#>  1.20230420  0.67691229  1.20232097  0.67692174 31.24891694 31.24987633 
#>     AUMCLST     AUMCIFO     AUMCIFP     AUMCPEO     AUMCPEP        VZFO 
#>  8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 30.48674823 
#>        VZFP        CLFO        CLFP    MRTEVLST    MRTEVIFO    MRTEVIFP 
#> 30.48632281  1.47729627  1.47727565  9.79748335 20.80003053 20.80036832 
#> attr(,"units")
#>  [1] ""              "mmol/L"        "mmol/L/mmol"   "h"            
#>  [5] "h"             "mmol/L"        "mmol/L"        "h"            
#>  [9] "h"             "/h"            "h"             "h"            
#> [13] ""              ""              ""              ""             
#> [17] "h*mmol/L"      "h*mmol/L"      "h*mmol/L"      "h*mmol/L/mmol"
#> [21] "h*mmol/L"      "h*mmol/L/mmol" "%"             "%"            
#> [25] "h2*mmol/L"     "h2*mmol/L"     "h2*mmol/L"     "%"            
#> [29] "%"             "L"             "L"             "L/h"          
#> [33] "L/h"           "h"             "h"             "h"            
#> attr(,"UsedPoints")
#> [1]  9 10 11

sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
#>          b0        CMAX       CMAXD        TMAX        TLAG        CLST 
#> -2.82508245  0.05828023  0.03281250  1.12000000  0.00000000  0.01820563 
#>       CLSTP        TLST      LAMZHL        LAMZ      LAMZLL      LAMZUL 
#>  0.01820645 24.37000000 14.30437757  0.04845700  9.05000000 24.37000000 
#>     LAMZNPT      CORRXY          R2       R2ADJ      AUCLST      AUCALL 
#>  3.00000000 -0.99999986  0.99999973  0.99999946  0.82659716  0.82659716 
#>      AUCIFO     AUCIFOD      AUCIFP     AUCIFPD      AUCPEO      AUCPEP 
#>  1.20230420  0.67691229  1.20232097  0.67692174 31.24891694 31.24987633 
#>     AUMCLST     AUMCIFO     AUMCIFP     AUMCPEO     AUMCPEP        VZFO 
#>  8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 30.48674823 
#>        VZFP        CLFO        CLFP    MRTEVLST    MRTEVIFO    MRTEVIFP 
#> 30.48632281  1.47729627  1.47727565  9.79748335 20.80003053 20.80036832 
#> attr(,"units")
#>  [1] ""              "mmol/L"        "mmol/L/mmol"   "h"            
#>  [5] "h"             "mmol/L"        "mmol/L"        "h"            
#>  [9] "h"             "/h"            "h"             "h"            
#> [13] ""              ""              ""              ""             
#> [17] "h*mmol/L"      "h*mmol/L"      "h*mmol/L"      "h*mmol/L/mmol"
#> [21] "h*mmol/L"      "h*mmol/L/mmol" "%"             "%"            
#> [25] "h2*mmol/L"     "h2*mmol/L"     "h2*mmol/L"     "%"            
#> [29] "%"             "L"             "L"             "L/h"          
#> [33] "L/h"           "h"             "h"             "h"            
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x, y/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)
#>          b0        CMAX       CMAXD        TMAX        TLAG        CLST 
#> -2.82508245  0.05828023          NA  1.12000000  0.00000000  0.01820563 
#>       CLSTP        TLST      LAMZHL        LAMZ      LAMZLL      LAMZUL 
#>  0.01820645 24.37000000 14.30437757  0.04845700  9.05000000 24.37000000 
#>     LAMZNPT      CORRXY          R2       R2ADJ      AUCLST      AUCALL 
#>  3.00000000 -0.99999986  0.99999973  0.99999946  0.82659716  0.82659716 
#>      AUCIFO     AUCIFOD      AUCIFP     AUCIFPD      AUCPEO      AUCPEP 
#>  1.20230420          NA  1.20232097          NA 31.24891694 31.24987633 
#>     AUMCLST     AUMCIFO     AUMCIFP     AUMCPEO     AUMCPEP        VZFO 
#>  8.09857188 25.00796396 25.00871908 67.61602869 67.61700649  0.00000000 
#>        VZFP        CLFO        CLFP    MRTEVLST    MRTEVIFO    MRTEVIFP 
#>  0.00000000  0.00000000  0.00000000  9.79748335 20.80003053 20.80036832 
#> attr(,"units")
#>  [1] ""              "mmol/L"        "mmol/L/mmol"   "h"            
#>  [5] "h"             "mmol/L"        "mmol/L"        "h"            
#>  [9] "h"             "/h"            "h"             "h"            
#> [13] ""              ""              ""              ""             
#> [17] "h*mmol/L"      "h*mmol/L"      "h*mmol/L"      "h*mmol/L/mmol"
#> [21] "h*mmol/L"      "h*mmol/L/mmol" "%"             "%"            
#> [25] "h2*mmol/L"     "h2*mmol/L"     "h2*mmol/L"     "%"            
#> [29] "%"             "L"             "L"             "L/h"          
#> [33] "L/h"           "h"             "h"             "h"            
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x, y/MW, dose=as.numeric(NA), doseUnit="mmol", concUnit="mmol/L", timeUnit="h", 
     MW=MW)
#>          b0        CMAX       CMAXD        TMAX        TLAG        CLST 
#> -2.82508245  0.05828023          NA  1.12000000  0.00000000  0.01820563 
#>       CLSTP        TLST      LAMZHL        LAMZ      LAMZLL      LAMZUL 
#>  0.01820645 24.37000000 14.30437757  0.04845700  9.05000000 24.37000000 
#>     LAMZNPT      CORRXY          R2       R2ADJ      AUCLST      AUCALL 
#>  3.00000000 -0.99999986  0.99999973  0.99999946  0.82659716  0.82659716 
#>      AUCIFO     AUCIFOD      AUCIFP     AUCIFPD      AUCPEO      AUCPEP 
#>  1.20230420          NA  1.20232097          NA 31.24891694 31.24987633 
#>     AUMCLST     AUMCIFO     AUMCIFP     AUMCPEO     AUMCPEP        VZFO 
#>  8.09857188 25.00796396 25.00871908 67.61602869 67.61700649          NA 
#>        VZFP        CLFO        CLFP    MRTEVLST    MRTEVIFO    MRTEVIFP 
#>          NA          NA          NA  9.79748335 20.80003053 20.80036832 
#> attr(,"units")
#>  [1] ""              "mmol/L"        "mmol/L/mmol"   "h"            
#>  [5] "h"             "mmol/L"        "mmol/L"        "h"            
#>  [9] "h"             "/h"            "h"             "h"            
#> [13] ""              ""              ""              ""             
#> [17] "h*mmol/L"      "h*mmol/L"      "h*mmol/L"      "h*mmol/L/mmol"
#> [21] "h*mmol/L"      "h*mmol/L/mmol" "%"             "%"            
#> [25] "h2*mmol/L"     "h2*mmol/L"     "h2*mmol/L"     "%"            
#> [29] "%"             "L"             "L"             "L/h"          
#> [33] "L/h"           "h"             "h"             "h"            
#> attr(,"UsedPoints")
#> [1]  9 10 11

sNCA(x, y, dose=320, concUnit="mg/L", timeUnit="hr")
#>           b0         CMAX        CMAXD         TMAX         TLAG         CLST 
#>    2.3687851   10.5000000    0.0328125    1.1200000    0.0000000    3.2800000 
#>        CLSTP         TLST       LAMZHL         LAMZ       LAMZLL       LAMZUL 
#>    3.2801465   24.3700000   14.3043776    0.0484570    9.0500000   24.3700000 
#>      LAMZNPT       CORRXY           R2        R2ADJ       AUCLST       AUCALL 
#>    3.0000000   -0.9999999    0.9999997    0.9999995  148.9230500  148.9230500 
#>       AUCIFO      AUCIFOD       AUCIFP      AUCIFPD       AUCPEO       AUCPEP 
#>  216.6119330    0.6769123  216.6149558    0.6769217   31.2489169   31.2498763 
#>      AUMCLST      AUMCIFO      AUMCIFP      AUMCPEO      AUMCPEP         VZFO 
#> 1459.0711035 4505.5348194 4505.6708646   67.6160287   67.6170065   30.4867482 
#>         VZFP         CLFO         CLFP     MRTEVLST     MRTEVIFO     MRTEVIFP 
#>   30.4863228    1.4772963    1.4772757    9.7974834   20.8000305   20.8003683 
#> attr(,"units")
#>  [1] ""           "mg/L"       "mg/L/mg"    "hr"         "hr"        
#>  [6] "mg/L"       "mg/L"       "hr"         "hr"         "/hr"       
#> [11] "hr"         "hr"         ""           ""           ""          
#> [16] ""           "hr*mg/L"    "hr*mg/L"    "hr*mg/L"    "hr*mg/L/mg"
#> [21] "hr*mg/L"    "hr*mg/L/mg" "%"          "%"          "hr2*mg/L"  
#> [26] "hr2*mg/L"   "hr2*mg/L"   "%"          "%"          "L"         
#> [31] "L"          "L/hr"       "L/hr"       "hr"         "hr"        
#> [36] "hr"        
#> attr(,"UsedPoints")
#> [1]  9 10 11
sNCA(x*60, y, dose=320, concUnit="mg/L", timeUnit="min")
#>            b0          CMAX         CMAXD          TMAX          TLAG 
#>  2.368785e+00  1.050000e+01  3.281250e-02  6.720000e+01  0.000000e+00 
#>          CLST         CLSTP          TLST        LAMZHL          LAMZ 
#>  3.280000e+00  3.280146e+00  1.462200e+03  8.582627e+02  8.076166e-04 
#>        LAMZLL        LAMZUL       LAMZNPT        CORRXY            R2 
#>  5.430000e+02  1.462200e+03  3.000000e+00 -9.999999e-01  9.999997e-01 
#>         R2ADJ        AUCLST        AUCALL        AUCIFO       AUCIFOD 
#>  9.999995e-01  8.935383e+03  8.935383e+03  1.299672e+04  4.061474e+01 
#>        AUCIFP       AUCIFPD        AUCPEO        AUCPEP       AUMCLST 
#>  1.299690e+04  4.061530e+01  3.124892e+01  3.124988e+01  5.252656e+06 
#>       AUMCIFO       AUMCIFP       AUMCPEO       AUMCPEP          VZFO 
#>  1.621993e+07  1.622042e+07  6.761603e+01  6.761701e+01  3.048675e+01 
#>          VZFP          CLFO          CLFP      MRTEVLST      MRTEVIFO 
#>  3.048632e+01  2.462160e-02  2.462126e-02  5.878490e+02  1.248002e+03 
#>      MRTEVIFP 
#>  1.248022e+03 
#> attr(,"units")
#>  [1] ""            "mg/L"        "mg/L/mg"     "min"         "min"        
#>  [6] "mg/L"        "mg/L"        "min"         "min"         "/min"       
#> [11] "min"         "min"         ""            ""            ""           
#> [16] ""            "min*mg/L"    "min*mg/L"    "min*mg/L"    "min*mg/L/mg"
#> [21] "min*mg/L"    "min*mg/L/mg" "%"           "%"           "min2*mg/L"  
#> [26] "min2*mg/L"   "min2*mg/L"   "%"           "%"           "L"          
#> [31] "L"           "L/min"       "L/min"       "min"         "min"        
#> [36] "min"        
#> attr(,"UsedPoints")
#> [1]  9 10 11