sNCA.RdThis is the work-horse function for NCA.
sNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", concUnit = "ug/L", iAUC = "", down = "Linear", MW = 0, returnNA = TRUE)
| x | usually time |
|---|---|
| y | usually concentration |
| dose | given amount |
| adm | one of |
| dur | duration of infusion |
| doseUnit | unit of dose |
| timeUnit | unit of time |
| concUnit | unit of concentration |
| iAUC | interval AUCs to calculate |
| down | either of |
| MW | molecular weight of the drug |
| returnNA | if |
This will replace IndiNCA.
maximum concentration, Cmax
dose normalized Cmax, CMAX / Dose, Cmax / Dose
time of maximum concentration, Tmax
time to observe the first non-zero concentration, for extravascular administration only
last positive concentration observed, Clast
last positive concentration predicted, Clast_pred
time of last positive concentration, Tlast
half-life by lambda z, ln(2)/LAMZ
lambda_z negative of best fit terminal slope
earliest time for LAMZ
last time for LAMZ
number of points for LAMZ
correlation of log(concentration) and time
R-squared
R-squared adjusted
back extrapolated concentration at time 0, for bolus intravascular administration only
AUC from 0 to TLST
AUC using all the given points, including trailing zero concentrations
AUC infinity observed
AUCIFO / Dose
AUC infinity predicted using CLSTP instead of CLST
AUCIFP / Dose
AUC % extrapolation observed
AUC % extrapolated for AUCIFP
AUC % back extrapolation observed, for bolus IV administration only
AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only
AUMC to the TLST
AUMC infinity observed using CLST
AUMC infinity determined by CLSTP
AUMC % extrapolated observed
AUMC % extrapolated predicted
mean residence time (MRT) to TLST, for intravascular administration
mean residence time (MRT) infinity using CLST, for intravascular administration
mean residence time (MRT) infinity using CLSTP, for intravascular administration
mean residence time (MRT) to TLST, for extravascular administration
mean residence time (MRT) infinity using CLST, for extravascular administration
mean residence time (MRT) infinity using CLSTP, for extravascular administration
volume of distribution determined by LAMZ and AUCIFO, for intravascular administration
volume of distribution determined by LAMZ and AUCIFP, for intravascular administration
VZO for extravascular administration, VZO/F, F is bioavailability
VZP for extravascular administration, VZP/F, F is bioavailability
clearance using AUCIFO, for intravascular administration
clearance using AUCIFP, for intravascular administration
CLO for extravascular administration, CLO/F, F is bioavailability
CLP for extravascular administration, CLP/F, F is bioavailability
volume of distribution at steady state using CLST, for intravascular administration only
volume of distribution at steady state using CLSTP, for intravascular administration only
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
help, tblNCA
# For one subject x = Theoph[Theoph$Subject=="1","Time"] y = Theoph[Theoph$Subject=="1","conc"] sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.0000000 -0.9999999 0.9999997 0.9999995 NA 148.9230500 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 148.9230500 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.2498763 NA NA 1459.0711035 4505.5348194 4505.6708646 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.6160287 67.6170065 NA NA NA 9.7974834 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.8000305 20.8003683 NA NA 30.4867482 30.4863228 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.4772963 1.4772757 NA NA #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L"sNCA(x, y, dose=320, concUnit="mg/L", returnNA=FALSE)#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL #> 3.0000000 -0.9999999 0.9999997 0.9999995 148.9230500 148.9230500 #> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP #> 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 31.2498763 #> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP MRTEVLST #> 1459.0711035 4505.5348194 4505.6708646 67.6160287 67.6170065 9.7974834 #> MRTEVIFO MRTEVIFP VZFO VZFP CLFO CLFP #> 20.8000305 20.8003683 30.4867482 30.4863228 1.4772963 1.4772757 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "h*mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" "%" #> [25] "h2*mg/L" "h2*mg/L" "h2*mg/L" "%" "%" "h" #> [31] "h" "h" "L" "L" "L/h" "L/h"iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.0000000 -0.9999999 0.9999997 0.9999995 NA 148.9230500 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 148.9230500 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.2498763 NA NA 1459.0711035 4505.5348194 4505.6708646 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.6160287 67.6170065 NA NA NA 9.7974834 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.8000305 20.8003683 NA NA 30.4867482 30.4863228 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.4772963 1.4772757 NA NA #> AUC[0-12h] AUC[0-24h] #> 91.7355220 147.6945866 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L" #> [49] "h*mg/L" "h*mg/L"MW = 180.164 # Molecular weight of theophylline sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h")#> Warning: Molecular weight should be given for more informative results!#> b0 CMAX CMAXD TMAX TLAG #> -2.8250824530 0.0582802336 0.0001821257 1.1200000000 0.0000000000 #> CLST CLSTP TLST LAMZHL LAMZ #> 0.0182056349 0.0182064479 24.3700000000 14.3043775711 0.0484569970 #> LAMZLL LAMZUL LAMZNPT CORRXY R2 #> 9.0500000000 24.3700000000 3.0000000000 -0.9999998648 0.9999997297 #> R2ADJ C0 AUCLST AUCALL AUCIFO #> 0.9999994593 NA 0.8265971559 0.8265971559 1.2023041953 #> AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP #> 0.0037572006 1.2023209731 0.0037572530 31.2489169405 31.2498763313 #> AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> NA NA 8.0985718762 25.0079639629 25.0087190814 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP #> 67.6160286851 67.6170064935 NA NA NA #> MRTEVLST MRTEVIFO MRTEVIFP VZO VZP #> 9.7974833547 20.8000305256 20.8003683211 NA NA #> VZFO VZFP CLO CLP CLFO #> NA NA NA NA NA #> CLFP VSSO VSSP #> NA NA NA #> attr(,"units") #> [1] "" "mmol/L" "mmol/L/mg" "h" "h" #> [6] "mmol/L" "mmol/L" "h" "h" "/h" #> [11] "h" "h" "" "" "" #> [16] "" "mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L" #> [21] "h*mmol/L/mg" "h*mmol/L" "h*mmol/L/mg" "%" "%" #> [26] "%" "%" "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" #> [31] "%" "%" "h" "h" "h" #> [36] "h" "h" "h" "L" "L" #> [41] "L" "L" "L/h" "L/h" "L/h" #> [46] "L/h" "L" "L"sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h", MW=MW)#> b0 CMAX CMAXD TMAX TLAG #> -2.8250824530 0.0582802336 0.0001821257 1.1200000000 0.0000000000 #> CLST CLSTP TLST LAMZHL LAMZ #> 0.0182056349 0.0182064479 24.3700000000 14.3043775711 0.0484569970 #> LAMZLL LAMZUL LAMZNPT CORRXY R2 #> 9.0500000000 24.3700000000 3.0000000000 -0.9999998648 0.9999997297 #> R2ADJ C0 AUCLST AUCALL AUCIFO #> 0.9999994593 NA 0.8265971559 0.8265971559 1.2023041953 #> AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP #> 0.0037572006 1.2023209731 0.0037572530 31.2489169405 31.2498763313 #> AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> NA NA 8.0985718762 25.0079639629 25.0087190814 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP #> 67.6160286851 67.6170064935 NA NA NA #> MRTEVLST MRTEVIFO MRTEVIFP VZO VZP #> 9.7974833547 20.8000305256 20.8003683211 NA NA #> VZFO VZFP CLO CLP CLFO #> 30.4867482346 30.4863228055 NA NA 1.4772962667 #> CLFP VSSO VSSP #> 1.4772756517 NA NA #> attr(,"units") #> [1] "" "mmol/L" "mmol/L/mg" "h" "h" #> [6] "mmol/L" "mmol/L" "h" "h" "/h" #> [11] "h" "h" "" "" "" #> [16] "" "mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L" #> [21] "h*mmol/L/mg" "h*mmol/L" "h*mmol/L/mg" "%" "%" #> [26] "%" "%" "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" #> [31] "%" "%" "h" "h" "h" #> [36] "h" "h" "h" "L" "L" #> [41] "L" "L" "L/h" "L/h" "L/h" #> [46] "L/h" "L" "L"sNCA(x, y, dose=320/MW, doseUnit="mmol", concUnit="mg/L", timeUnit="h", MW=MW)#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 5.9116312 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.0000000 -0.9999999 0.9999997 0.9999995 NA 148.9230500 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 148.9230500 216.6119330 121.9552259 216.6149558 121.9569278 31.2489169 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.2498763 NA NA 1459.0711035 4505.5348194 4505.6708646 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.6160287 67.6170065 NA NA NA 9.7974834 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.8000305 20.8003683 NA NA 30.4867482 30.4863228 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.4772963 1.4772757 NA NA #> attr(,"units") #> [1] "" "mg/L" "mg/L/mmol" "h" "h" #> [6] "mg/L" "mg/L" "h" "h" "/h" #> [11] "h" "h" "" "" "" #> [16] "" "mg/L" "h*mg/L" "h*mg/L" "h*mg/L" #> [21] "h*mg/L/mmol" "h*mg/L" "h*mg/L/mmol" "%" "%" #> [26] "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" #> [36] "h" "h" "h" "L" "L" #> [41] "L" "L" "L/h" "L/h" "L/h" #> [46] "L/h" "L" "L"sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)#> b0 CMAX CMAXD TMAX TLAG CLST #> -2.82508245 0.05828023 0.03281250 1.12000000 0.00000000 0.01820563 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 0.01820645 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.00000000 -0.99999986 0.99999973 0.99999946 NA 0.82659716 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 0.82659716 1.20230420 0.67691229 1.20232097 0.67692174 31.24891694 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.24987633 NA NA 8.09857188 25.00796396 25.00871908 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.61602869 67.61700649 NA NA NA 9.79748335 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.80003053 20.80036832 NA NA 30.48674823 30.48632281 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.47729627 1.47727565 NA NA #> attr(,"units") #> [1] "" "mmol/L" "mmol/L/mmol" "h" #> [5] "h" "mmol/L" "mmol/L" "h" #> [9] "h" "/h" "h" "h" #> [13] "" "" "" "" #> [17] "mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L" #> [21] "h*mmol/L/mmol" "h*mmol/L" "h*mmol/L/mmol" "%" #> [25] "%" "%" "%" "h2*mmol/L" #> [29] "h2*mmol/L" "h2*mmol/L" "%" "%" #> [33] "h" "h" "h" "h" #> [37] "h" "h" "L" "L" #> [41] "L" "L" "L/h" "L/h" #> [45] "L/h" "L/h" "L" "L"sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW, returnNA=FALSE)#> b0 CMAX CMAXD TMAX TLAG CLST #> -2.82508245 0.05828023 0.03281250 1.12000000 0.00000000 0.01820563 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 0.01820645 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000 #> LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL #> 3.00000000 -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716 #> AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP #> 1.20230420 0.67691229 1.20232097 0.67692174 31.24891694 31.24987633 #> AUMCLST AUMCIFO AUMCIFP AUMCPEO AUMCPEP MRTEVLST #> 8.09857188 25.00796396 25.00871908 67.61602869 67.61700649 9.79748335 #> MRTEVIFO MRTEVIFP VZFO VZFP CLFO CLFP #> 20.80003053 20.80036832 30.48674823 30.48632281 1.47729627 1.47727565 #> attr(,"units") #> [1] "" "mmol/L" "mmol/L/mmol" "h" #> [5] "h" "mmol/L" "mmol/L" "h" #> [9] "h" "/h" "h" "h" #> [13] "" "" "" "" #> [17] "h*mmol/L" "h*mmol/L" "h*mmol/L" "h*mmol/L/mmol" #> [21] "h*mmol/L" "h*mmol/L/mmol" "%" "%" #> [25] "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" "%" #> [29] "%" "h" "h" "h" #> [33] "L" "L" "L/h" "L/h"sNCA(x, y/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW, returnNA=FALSE)#> b0 CMAX TMAX TLAG CLST CLSTP #> -2.82508245 0.05828023 1.12000000 0.00000000 0.01820563 0.01820645 #> TLST LAMZHL LAMZ LAMZLL LAMZUL LAMZNPT #> 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000 3.00000000 #> CORRXY R2 R2ADJ AUCLST AUCALL AUCIFO #> -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716 1.20230420 #> AUCIFP AUCPEO AUCPEP AUMCLST AUMCIFO AUMCIFP #> 1.20232097 31.24891694 31.24987633 8.09857188 25.00796396 25.00871908 #> AUMCPEO AUMCPEP MRTEVLST MRTEVIFO MRTEVIFP VZFO #> 67.61602869 67.61700649 9.79748335 20.80003053 20.80036832 0.00000000 #> VZFP CLFO CLFP #> 0.00000000 0.00000000 0.00000000 #> attr(,"units") #> [1] "" "mmol/L" "h" "h" "mmol/L" "mmol/L" #> [7] "h" "h" "/h" "h" "h" "" #> [13] "" "" "" "h*mmol/L" "h*mmol/L" "h*mmol/L" #> [19] "h*mmol/L" "%" "%" "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" #> [25] "%" "%" "h" "h" "h" "L" #> [31] "L" "L/h" "L/h"sNCA(x, y/MW, dose=as.numeric(NA), doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW, returnNA=FALSE)#> b0 CMAX TMAX TLAG CLST CLSTP #> -2.82508245 0.05828023 1.12000000 0.00000000 0.01820563 0.01820645 #> TLST LAMZHL LAMZ LAMZLL LAMZUL LAMZNPT #> 24.37000000 14.30437757 0.04845700 9.05000000 24.37000000 3.00000000 #> CORRXY R2 R2ADJ AUCLST AUCALL AUCIFO #> -0.99999986 0.99999973 0.99999946 0.82659716 0.82659716 1.20230420 #> AUCIFP AUCPEO AUCPEP AUMCLST AUMCIFO AUMCIFP #> 1.20232097 31.24891694 31.24987633 8.09857188 25.00796396 25.00871908 #> AUMCPEO AUMCPEP MRTEVLST MRTEVIFO MRTEVIFP #> 67.61602869 67.61700649 9.79748335 20.80003053 20.80036832 #> attr(,"units") #> [1] "" "mmol/L" "h" "h" "mmol/L" "mmol/L" #> [7] "h" "h" "/h" "h" "h" "" #> [13] "" "" "" "h*mmol/L" "h*mmol/L" "h*mmol/L" #> [19] "h*mmol/L" "%" "%" "h2*mmol/L" "h2*mmol/L" "h2*mmol/L" #> [25] "%" "%" "h" "h" "h"sNCA(x, y, dose=320, concUnit="mg/L", timeUnit="hr")#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.0000000 -0.9999999 0.9999997 0.9999995 NA 148.9230500 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 148.9230500 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.2498763 NA NA 1459.0711035 4505.5348194 4505.6708646 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.6160287 67.6170065 NA NA NA 9.7974834 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.8000305 20.8003683 NA NA 30.4867482 30.4863228 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.4772963 1.4772757 NA NA #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "hr" "hr" #> [6] "mg/L" "mg/L" "hr" "hr" "/hr" #> [11] "hr" "hr" "" "" "" #> [16] "" "mg/L" "hr*mg/L" "hr*mg/L" "hr*mg/L" #> [21] "hr*mg/L/mg" "hr*mg/L" "hr*mg/L/mg" "%" "%" #> [26] "%" "%" "hr2*mg/L" "hr2*mg/L" "hr2*mg/L" #> [31] "%" "%" "hr" "hr" "hr" #> [36] "hr" "hr" "hr" "L" "L" #> [41] "L" "L" "L/hr" "L/hr" "L/hr" #> [46] "L/hr" "L" "L"sNCA(x*60, y, dose=320, concUnit="mg/L", timeUnit="min")#> b0 CMAX CMAXD TMAX TLAG #> 2.368785e+00 1.050000e+01 3.281250e-02 6.720000e+01 0.000000e+00 #> CLST CLSTP TLST LAMZHL LAMZ #> 3.280000e+00 3.280146e+00 1.462200e+03 8.582627e+02 8.076166e-04 #> LAMZLL LAMZUL LAMZNPT CORRXY R2 #> 5.430000e+02 1.462200e+03 3.000000e+00 -9.999999e-01 9.999997e-01 #> R2ADJ C0 AUCLST AUCALL AUCIFO #> 9.999995e-01 NA 8.935383e+03 8.935383e+03 1.299672e+04 #> AUCIFOD AUCIFP AUCIFPD AUCPEO AUCPEP #> 4.061474e+01 1.299690e+04 4.061530e+01 3.124892e+01 3.124988e+01 #> AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> NA NA 5.252656e+06 1.621993e+07 1.622042e+07 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP #> 6.761603e+01 6.761701e+01 NA NA NA #> MRTEVLST MRTEVIFO MRTEVIFP VZO VZP #> 5.878490e+02 1.248002e+03 1.248022e+03 NA NA #> VZFO VZFP CLO CLP CLFO #> 3.048675e+01 3.048632e+01 NA NA 2.462160e-02 #> CLFP VSSO VSSP #> 2.462126e-02 NA NA #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "min" "min" #> [6] "mg/L" "mg/L" "min" "min" "/min" #> [11] "min" "min" "" "" "" #> [16] "" "mg/L" "min*mg/L" "min*mg/L" "min*mg/L" #> [21] "min*mg/L/mg" "min*mg/L" "min*mg/L/mg" "%" "%" #> [26] "%" "%" "min2*mg/L" "min2*mg/L" "min2*mg/L" #> [31] "%" "%" "min" "min" "min" #> [36] "min" "min" "min" "L" "L" #> [41] "L" "L" "L/min" "L/min" "L/min" #> [46] "L/min" "L" "L"