pkr-package.RdIt conducts a noncompartmental analysis(NCA) as closely as possible to the most widely used commercial pharmacokinetic analysis software.
The main functions are
NCA to perform NCA for many subjects.
IndiNCA to perform NCA for one subject.
Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.
Shargel L, Yu A. Applied Biopharmaceutics and Pharmacokinetics. 7th ed. 2015.
Rowland M, Tozer TN. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. 4th ed. 2011.
Gibaldi M, Perrier D. Pharmacokinetics. 2nd ed. revised and expanded. 1982.
# Theoph and Indometh data: dose in mg, conc in mg/L, time in h NCA(Theoph, "Subject", "Time", "conc", dose=320, uConc="mg/L")#> Subject CMAX CMAXD TMAX TLAG CLST CLSTP TLST LAMZHL LAMZ #> 1 1 10.50 0.03281250 1.12 0 3.28 3.2801465 24.37 14.304378 0.04845700 #> 2 2 8.33 0.02603125 1.92 0 0.90 0.8886398 24.30 6.659342 0.10408644 #> 3 3 8.20 0.02562500 1.02 0 1.05 1.0550967 24.17 6.766087 0.10244431 #> 4 4 8.60 0.02687500 1.07 0 1.15 1.1564216 24.65 6.981247 0.09928702 #> 5 5 11.40 0.03562500 1.00 0 1.57 1.5556951 24.35 8.002264 0.08661888 #> 6 6 6.44 0.02012500 1.15 0 0.92 0.9412712 23.85 7.894998 0.08779574 #> 7 7 7.09 0.02215625 3.48 0 1.15 1.1607192 24.22 7.846668 0.08833650 #> 8 8 7.56 0.02362500 2.02 0 1.25 1.2285268 24.12 8.510038 0.08145054 #> 9 9 9.03 0.02821875 0.63 0 1.12 1.1164831 24.43 8.405999 0.08245863 #> 10 10 10.21 0.03190625 3.55 0 2.42 2.4136923 23.70 9.246916 0.07495982 #> 11 11 8.00 0.02500000 0.98 0 0.86 0.8598066 24.08 7.261237 0.09545856 #> 12 12 9.75 0.03046875 3.52 0 1.17 1.1755390 24.15 6.286508 0.11025949 #> LAMZLL LAMZUL LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL #> 1 9.05 24.37 3 -0.9999999 0.9999997 0.9999995 148.92305 148.92305 #> 2 7.03 24.30 4 -0.9985967 0.9971954 0.9957931 91.52680 91.52680 #> 3 9.00 24.17 3 -0.9996624 0.9993250 0.9986499 99.28650 99.28650 #> 4 9.02 24.65 3 -0.9994619 0.9989241 0.9978483 106.79630 106.79630 #> 5 7.02 24.35 4 -0.9993234 0.9986472 0.9979708 121.29440 121.29440 #> 6 2.03 23.85 7 -0.9991203 0.9982413 0.9978896 73.77555 73.77555 #> 7 6.98 24.22 4 -0.9993349 0.9986702 0.9980053 90.75340 90.75340 #> 8 3.53 24.12 6 -0.9954961 0.9910124 0.9887655 88.55995 88.55995 #> 9 8.80 24.43 3 -0.9997218 0.9994437 0.9988873 86.32615 86.32615 #> 10 9.38 23.70 3 -0.9997543 0.9995087 0.9990174 138.36810 138.36810 #> 11 9.03 24.08 3 -0.9999991 0.9999983 0.9999965 80.09360 80.09360 #> 12 9.03 24.15 3 -0.9996984 0.9993968 0.9987936 119.97750 119.97750 #> AUCIFO AUCIFOD AUCPEO AUCIFP AUCIFPD AUCPEP AUMCLST #> 1 216.61193 0.6769123 216.61496 0.6769217 31.248917 31.249876 1459.0711 #> 2 100.17346 0.3130421 100.06432 0.3127010 8.631687 8.532030 706.5866 #> 3 109.53597 0.3422999 109.58572 0.3424554 9.357173 9.398325 803.1859 #> 4 118.37888 0.3699340 118.44356 0.3701361 9.784331 9.833594 901.0842 #> 5 139.41978 0.4356868 139.25463 0.4351707 13.000579 12.897403 1017.1143 #> 6 84.25442 0.2632951 84.49670 0.2640522 12.437174 12.688246 609.1524 #> 7 103.77180 0.3242869 103.89315 0.3246661 12.545221 12.647366 782.4199 #> 8 103.90669 0.3247084 103.64305 0.3238845 14.769730 14.552931 739.5346 #> 9 99.90872 0.3122147 99.86607 0.3120815 13.594978 13.558076 705.2296 #> 10 170.65206 0.5332877 170.56791 0.5330247 18.918002 18.878001 1278.1800 #> 11 89.10274 0.2784461 89.10072 0.2784397 10.110962 10.108918 617.2422 #> 12 130.58883 0.4080901 130.63907 0.4082471 8.125757 8.161087 977.8807 #> AUMCIFO AUMCPEO AUMCIFP AUMCPEP MRTEVLST MRTEVIFO MRTEVIFP VZFO #> 1 4505.5348 4505.6709 67.61603 67.61701 9.797483 20.800031 20.800368 30.48675 #> 2 999.7723 996.0716 29.32525 29.06267 7.719996 9.980411 9.954313 30.69044 #> 3 1150.9648 1152.6529 30.21629 30.31850 8.089578 10.507642 10.518276 28.51710 #> 4 1303.2524 1305.4981 30.85881 30.97775 8.437410 11.009163 11.022112 27.22596 #> 5 1667.7216 1661.7937 39.01174 38.79419 8.385501 11.961873 11.933490 26.49799 #> 6 978.4285 986.9665 37.74176 38.28034 8.256833 11.612785 11.680533 43.25973 #> 7 1245.0984 1249.4111 37.16000 37.37691 8.621383 11.998427 12.025924 34.90844 #> 8 1298.1158 1288.5201 43.03015 42.60589 8.350666 12.493092 12.432287 37.81051 #> 9 1201.7715 1200.2124 41.31750 41.24126 8.169363 12.028695 12.018220 38.84279 #> 10 2473.9934 2470.8765 48.33535 48.27018 9.237534 14.497296 14.486174 25.01554 #> 11 928.5600 928.4900 33.52694 33.52193 7.706511 10.421227 10.420679 37.62219 #> 12 1330.3840 1332.0528 26.49636 26.58844 8.150534 10.187579 10.196436 22.22429 #> VZFP CLFO CLFP #> 1 30.48632 1.477296 1.477276 #> 2 30.72392 3.194459 3.197943 #> 3 28.50415 2.921415 2.920088 #> 4 27.21110 2.703185 2.701709 #> 5 26.52942 2.295227 2.297949 #> 6 43.13569 3.798020 3.787130 #> 7 34.86767 3.083689 3.080088 #> 8 37.90669 3.079686 3.087520 #> 9 38.85938 3.202924 3.204292 #> 10 25.02788 1.875160 1.876086 #> 11 37.62304 3.591360 3.591441 #> 12 22.21575 2.450439 2.449497#> Subject CMAX CMAXD TMAX C0 AUCPBEO AUCPBEP CLST CLSTP TLST #> 1 1 1.50 0.0600 0.25 0.05 0.05024851 8 4.378127 0.1583205 5.00 #> 2 2 2.03 0.0812 0.25 0.08 0.07475591 8 2.293063 0.3022800 0.75 #> 3 3 2.72 0.1088 0.25 0.08 0.03997258 8 1.642947 0.4218926 0.50 #> 4 4 1.85 0.0740 0.25 0.07 0.03196011 8 1.521910 0.4554455 0.25 #> 5 5 2.05 0.0820 0.25 0.06 0.04957149 8 2.742446 0.2527478 1.00 #> 6 6 2.31 0.0924 0.25 0.09 0.05624247 8 1.960699 0.3535205 0.75 #> LAMZHL LAMZ LAMZLL LAMZUL LAMZNPT CORRXY R2 R2ADJ #> 1 8 3 -0.9985323 0.9970667 0.9941335 2.393617 2.040452 2.040452 #> 2 8 9 -0.9734830 0.9476691 0.9401933 2.528160 3.248520 3.248520 #> 3 8 10 -0.9358558 0.8758261 0.8603043 4.965369 3.554421 3.554421 #> 4 8 11 -0.9342510 0.8728249 0.8586943 2.462230 2.785279 2.785279 #> 5 8 8 -0.9355449 0.8752442 0.8544516 4.040865 2.458858 2.458858 #> 6 8 9 -0.9507649 0.9039538 0.8902329 3.705625 3.335703 3.335703 #> AUCLST AUCALL AUCIFO AUCIFOD AUCPEO AUCIFP AUCIFPD AUCPEP #> 1 2.356267 0.09425069 2.357837 0.09431348 13.403196 13.460844 20.65564 20.64189 #> 2 3.513175 0.14052701 3.495827 0.13983307 7.533221 7.074344 16.21809 16.29857 #> 3 3.744043 0.14976171 3.649167 0.14596668 5.064624 2.596369 25.65866 26.32577 #> 4 2.938974 0.11755898 2.855452 0.11421808 5.229568 2.457520 18.34071 18.87718 #> 5 2.696249 0.10784996 2.654988 0.10619954 8.804484 7.387236 28.23768 28.67652 #> 6 3.590285 0.14361141 3.494796 0.13979183 7.090860 4.552269 20.94411 21.51637 #> AUMCLST AUMCIFO AUMCPEO AUMCIFP AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP #> 1 3.271250 7.792554 7.815026 58.02083 58.14153 1.603199 3.307161 3.314490 #> 2 6.398750 9.391522 9.195343 31.86674 30.41314 1.969743 2.673229 2.630377 #> 3 5.006250 6.972678 5.988790 28.20191 16.40632 1.408457 1.862339 1.641139 #> 4 4.381875 5.948903 5.097338 26.34146 14.03601 1.573227 2.024142 1.785125 #> 5 3.707500 6.545866 6.052534 43.36120 38.74467 1.507814 2.427768 2.279684 #> 6 5.532500 8.289291 7.255264 33.25726 23.74502 1.658571 2.308811 2.076019 #> VZO VZP CLO CLP VSSO VSSP #> 1 67.01598 66.97136 10.610002 10.602939 35.08898 35.14333 #> 2 23.54132 23.65814 7.116070 7.151384 19.02289 18.81084 #> 3 15.82695 16.23844 6.677274 6.850879 12.43535 11.24324 #> 4 18.67703 19.22334 8.506369 8.755181 17.21810 15.62909 #> 5 36.68535 37.25547 9.272141 9.416237 22.51060 21.46604 #> 6 19.69683 20.23502 6.963235 7.153494 16.07680 14.85079iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC#> Name Start End #> 1 AUC[0-12h] 0 12 #> 2 AUC[0-24h] 0 24#> Subject CMAX CMAXD TMAX TLAG CLST CLSTP TLST LAMZHL LAMZ #> 1 1 10.50 0.03281250 1.12 0 3.28 3.2801465 24.37 14.304378 0.04845700 #> 2 2 8.33 0.02603125 1.92 0 0.90 0.8886398 24.30 6.659342 0.10408644 #> 3 3 8.20 0.02562500 1.02 0 1.05 1.0550967 24.17 6.766087 0.10244431 #> 4 4 8.60 0.02687500 1.07 0 1.15 1.1564216 24.65 6.981247 0.09928702 #> 5 5 11.40 0.03562500 1.00 0 1.57 1.5556951 24.35 8.002264 0.08661888 #> 6 6 6.44 0.02012500 1.15 0 0.92 0.9412712 23.85 7.894998 0.08779574 #> 7 7 7.09 0.02215625 3.48 0 1.15 1.1607192 24.22 7.846668 0.08833650 #> 8 8 7.56 0.02362500 2.02 0 1.25 1.2285268 24.12 8.510038 0.08145054 #> 9 9 9.03 0.02821875 0.63 0 1.12 1.1164831 24.43 8.405999 0.08245863 #> 10 10 10.21 0.03190625 3.55 0 2.42 2.4136923 23.70 9.246916 0.07495982 #> 11 11 8.00 0.02500000 0.98 0 0.86 0.8598066 24.08 7.261237 0.09545856 #> 12 12 9.75 0.03046875 3.52 0 1.17 1.1755390 24.15 6.286508 0.11025949 #> LAMZLL LAMZUL LAMZNPT CORRXY R2 R2ADJ AUCLST AUCALL #> 1 9.05 24.37 3 -0.9999999 0.9999997 0.9999995 148.92305 148.92305 #> 2 7.03 24.30 4 -0.9985967 0.9971954 0.9957931 91.52680 91.52680 #> 3 9.00 24.17 3 -0.9996624 0.9993250 0.9986499 99.28650 99.28650 #> 4 9.02 24.65 3 -0.9994619 0.9989241 0.9978483 106.79630 106.79630 #> 5 7.02 24.35 4 -0.9993234 0.9986472 0.9979708 121.29440 121.29440 #> 6 2.03 23.85 7 -0.9991203 0.9982413 0.9978896 73.77555 73.77555 #> 7 6.98 24.22 4 -0.9993349 0.9986702 0.9980053 90.75340 90.75340 #> 8 3.53 24.12 6 -0.9954961 0.9910124 0.9887655 88.55995 88.55995 #> 9 8.80 24.43 3 -0.9997218 0.9994437 0.9988873 86.32615 86.32615 #> 10 9.38 23.70 3 -0.9997543 0.9995087 0.9990174 138.36810 138.36810 #> 11 9.03 24.08 3 -0.9999991 0.9999983 0.9999965 80.09360 80.09360 #> 12 9.03 24.15 3 -0.9996984 0.9993968 0.9987936 119.97750 119.97750 #> AUCIFO AUCIFOD AUCPEO AUCIFP AUCIFPD AUCPEP AUMCLST #> 1 216.61193 0.6769123 216.61496 0.6769217 31.248917 31.249876 1459.0711 #> 2 100.17346 0.3130421 100.06432 0.3127010 8.631687 8.532030 706.5866 #> 3 109.53597 0.3422999 109.58572 0.3424554 9.357173 9.398325 803.1859 #> 4 118.37888 0.3699340 118.44356 0.3701361 9.784331 9.833594 901.0842 #> 5 139.41978 0.4356868 139.25463 0.4351707 13.000579 12.897403 1017.1143 #> 6 84.25442 0.2632951 84.49670 0.2640522 12.437174 12.688246 609.1524 #> 7 103.77180 0.3242869 103.89315 0.3246661 12.545221 12.647366 782.4199 #> 8 103.90669 0.3247084 103.64305 0.3238845 14.769730 14.552931 739.5346 #> 9 99.90872 0.3122147 99.86607 0.3120815 13.594978 13.558076 705.2296 #> 10 170.65206 0.5332877 170.56791 0.5330247 18.918002 18.878001 1278.1800 #> 11 89.10274 0.2784461 89.10072 0.2784397 10.110962 10.108918 617.2422 #> 12 130.58883 0.4080901 130.63907 0.4082471 8.125757 8.161087 977.8807 #> AUMCIFO AUMCPEO AUMCIFP AUMCPEP MRTEVLST MRTEVIFO MRTEVIFP VZFO #> 1 4505.5348 4505.6709 67.61603 67.61701 9.797483 20.800031 20.800368 30.48675 #> 2 999.7723 996.0716 29.32525 29.06267 7.719996 9.980411 9.954313 30.69044 #> 3 1150.9648 1152.6529 30.21629 30.31850 8.089578 10.507642 10.518276 28.51710 #> 4 1303.2524 1305.4981 30.85881 30.97775 8.437410 11.009163 11.022112 27.22596 #> 5 1667.7216 1661.7937 39.01174 38.79419 8.385501 11.961873 11.933490 26.49799 #> 6 978.4285 986.9665 37.74176 38.28034 8.256833 11.612785 11.680533 43.25973 #> 7 1245.0984 1249.4111 37.16000 37.37691 8.621383 11.998427 12.025924 34.90844 #> 8 1298.1158 1288.5201 43.03015 42.60589 8.350666 12.493092 12.432287 37.81051 #> 9 1201.7715 1200.2124 41.31750 41.24126 8.169363 12.028695 12.018220 38.84279 #> 10 2473.9934 2470.8765 48.33535 48.27018 9.237534 14.497296 14.486174 25.01554 #> 11 928.5600 928.4900 33.52694 33.52193 7.706511 10.421227 10.420679 37.62219 #> 12 1330.3840 1332.0528 26.49636 26.58844 8.150534 10.187579 10.196436 22.22429 #> VZFP CLFO CLFP AUC[0-12h] AUC[0-24h] #> 1 30.48632 1.477296 1.477276 91.73552 147.69459 #> 2 30.72392 3.194459 3.197943 67.48030 91.24908 #> 3 28.50415 2.921415 2.920088 70.17971 99.10481 #> 4 27.21110 2.703185 2.701709 73.05115 105.99811 #> 5 26.52942 2.295227 2.297949 84.61490 120.73101 #> 6 43.13569 3.798020 3.787130 51.75887 73.91422 #> 7 34.86767 3.083689 3.080088 62.09875 90.49567 #> 8 37.90669 3.079686 3.087520 62.71486 88.40890 #> 9 38.85938 3.202924 3.204292 60.12123 85.82985 #> 10 25.02788 1.875160 1.876086 90.81742 139.08507 #> 11 37.62304 3.591360 3.591441 58.53963 80.02431 #> 12 22.21575 2.450439 2.449497 85.02136 119.79884#> Subject CMAX CMAXD TMAX C0 AUCPBEO AUCPBEP CLST CLSTP TLST #> 1 1 1.50 0.0600 0.25 0.05 0.05024851 8 4.378127 0.1583205 5.00 #> 2 2 2.03 0.0812 0.25 0.08 0.07475591 8 2.293063 0.3022800 0.75 #> 3 3 2.72 0.1088 0.25 0.08 0.03997258 8 1.642947 0.4218926 0.50 #> 4 4 1.85 0.0740 0.25 0.07 0.03196011 8 1.521910 0.4554455 0.25 #> 5 5 2.05 0.0820 0.25 0.06 0.04957149 8 2.742446 0.2527478 1.00 #> 6 6 2.31 0.0924 0.25 0.09 0.05624247 8 1.960699 0.3535205 0.75 #> LAMZHL LAMZ LAMZLL LAMZUL LAMZNPT CORRXY R2 R2ADJ #> 1 8 3 -0.9985323 0.9970667 0.9941335 2.393617 2.040452 2.040452 #> 2 8 9 -0.9734830 0.9476691 0.9401933 2.528160 3.248520 3.248520 #> 3 8 10 -0.9358558 0.8758261 0.8603043 4.965369 3.554421 3.554421 #> 4 8 11 -0.9342510 0.8728249 0.8586943 2.462230 2.785279 2.785279 #> 5 8 8 -0.9355449 0.8752442 0.8544516 4.040865 2.458858 2.458858 #> 6 8 9 -0.9507649 0.9039538 0.8902329 3.705625 3.335703 3.335703 #> AUCLST AUCALL AUCIFO AUCIFOD AUCPEO AUCIFP AUCIFPD AUCPEP #> 1 2.356267 0.09425069 2.357837 0.09431348 13.403196 13.460844 20.65564 20.64189 #> 2 3.513175 0.14052701 3.495827 0.13983307 7.533221 7.074344 16.21809 16.29857 #> 3 3.744043 0.14976171 3.649167 0.14596668 5.064624 2.596369 25.65866 26.32577 #> 4 2.938974 0.11755898 2.855452 0.11421808 5.229568 2.457520 18.34071 18.87718 #> 5 2.696249 0.10784996 2.654988 0.10619954 8.804484 7.387236 28.23768 28.67652 #> 6 3.590285 0.14361141 3.494796 0.13979183 7.090860 4.552269 20.94411 21.51637 #> AUMCLST AUMCIFO AUMCPEO AUMCIFP AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP #> 1 3.271250 7.792554 7.815026 58.02083 58.14153 1.603199 3.307161 3.314490 #> 2 6.398750 9.391522 9.195343 31.86674 30.41314 1.969743 2.673229 2.630377 #> 3 5.006250 6.972678 5.988790 28.20191 16.40632 1.408457 1.862339 1.641139 #> 4 4.381875 5.948903 5.097338 26.34146 14.03601 1.573227 2.024142 1.785125 #> 5 3.707500 6.545866 6.052534 43.36120 38.74467 1.507814 2.427768 2.279684 #> 6 5.532500 8.289291 7.255264 33.25726 23.74502 1.658571 2.308811 2.076019 #> VZO VZP CLO CLP VSSO VSSP AUC[0-12h] AUC[0-24h] #> 1 67.01598 66.97136 10.610002 10.602939 35.08898 35.14333 2.188947 2.331634 #> 2 23.54132 23.65814 7.116070 7.151384 19.02289 18.81084 3.429231 3.507581 #> 3 15.82695 16.23844 6.677274 6.850879 12.43535 11.24324 3.676377 3.726268 #> 4 18.67703 19.22334 8.506369 8.755181 17.21810 15.62909 2.884797 2.924002 #> 5 36.68535 37.25547 9.272141 9.416237 22.51060 21.46604 2.598511 2.682264 #> 6 19.69683 20.23502 6.963235 7.153494 16.07680 14.85079 3.497732 3.570236writeLines(NCA(Theoph, "Subject", "Time", "conc", dose=320, report="Text", uConc="mg/L"), "Theoph_Linear_CoreOutput.txt") writeLines(NCA(Theoph, "Subject", "Time", "conc", dose=320, fit="Log", report="Text", uConc="mg/L"), "Theoph_Log_CoreOutput.txt") writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", report="Text", uConc="mg/L"), "Indometh_Bolus_Linear_CoreOutput.txt") writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Bolus", fit="Log", report="Text", uConc="mg/L"), "Indometh_Bolus_Log_CoreOutput.txt") writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Infusion", dur=0.25, report="Text", uConc="mg/L"), "Indometh_Infusion_Linear_CoreOutput.txt") writeLines(NCA(Indometh, "Subject", "time", "conc", dose=25, adm="Infusion", dur=0.25, fit="Log", report="Text", uConc="mg/L"), "Indometh_Infusion_Log_CoreOutput.txt") sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], dose=320, concUnit="mg/L")#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.0000000 -0.9999999 0.9999997 0.9999995 NA 148.9230500 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 148.9230500 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.2498763 NA NA 1459.0711035 4505.5348194 4505.6708646 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.6160287 67.6170065 NA NA NA 9.7974834 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.8000305 20.8003683 NA NA 30.4867482 30.4863228 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.4772963 1.4772757 NA NA #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L"sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25, adm="Bolus", concUnit="mg/L")#> b0 CMAX CMAXD TMAX TLAG CLST #> -1.72421060 1.50000000 0.06000000 0.25000000 NA 0.05000000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 0.05024851 8.00000000 4.37812701 0.15832048 5.00000000 8.00000000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.00000000 -0.99853229 0.99706673 0.99413345 2.39361702 2.04045213 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 2.04045213 2.35626723 0.09425069 2.35783688 0.09431348 13.40319561 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 13.46084419 20.65564214 20.64189142 3.27125000 7.79255448 7.81502594 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 58.02082606 58.14153371 1.60319860 3.30716074 3.31448966 NA #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> NA NA 67.01597804 66.97136466 NA NA #> CLO CLP CLFO CLFP VSSO VSSP #> 10.61000197 10.60293876 NA NA 35.08898193 35.14333088 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L"sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25, adm="Infusion", dur=0.25, concUnit="mg/L")#> b0 CMAX CMAXD TMAX TLAG CLST #> -1.72421060 1.50000000 0.06000000 0.25000000 0.00000000 0.05000000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 0.05024851 8.00000000 4.37812701 0.15832048 5.00000000 8.00000000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.00000000 -0.99853229 0.99706673 0.99413345 NA 1.74125000 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 1.74125000 2.05706511 0.08228260 2.05863475 0.08234539 15.35270349 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 15.41724428 NA NA 3.27125000 7.79255448 7.81502594 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 58.02082606 58.14153371 1.75367911 3.66319049 3.67121783 NA #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> NA NA 76.76351746 76.70498779 NA NA #> CLO CLP CLFO CLFP VSSO VSSP #> 12.15323712 12.14397067 NA NA 44.51962266 44.58316170 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L"iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24)) ; iAUC#> Name Start End #> 1 AUC[0-12h] 0 12 #> 2 AUC[0-24h] 0 24sNCA(Theoph[Theoph$Subject==1,"Time"], Theoph[Theoph$Subject==1, "conc"], dose=320, iAUC=iAUC, concUnit="mg/L")#> b0 CMAX CMAXD TMAX TLAG CLST #> 2.3687851 10.5000000 0.0328125 1.1200000 0.0000000 3.2800000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 3.2801465 24.3700000 14.3043776 0.0484570 9.0500000 24.3700000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.0000000 -0.9999999 0.9999997 0.9999995 NA 148.9230500 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 148.9230500 216.6119330 0.6769123 216.6149558 0.6769217 31.2489169 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 31.2498763 NA NA 1459.0711035 4505.5348194 4505.6708646 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 67.6160287 67.6170065 NA NA NA 9.7974834 #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> 20.8000305 20.8003683 NA NA 30.4867482 30.4863228 #> CLO CLP CLFO CLFP VSSO VSSP #> NA NA 1.4772963 1.4772757 NA NA #> AUC[0-12h] AUC[0-24h] #> 91.7355220 147.6945866 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L" #> [49] "h*mg/L" "h*mg/L"sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25, adm="Bolus", iAUC=iAUC, concUnit="mg/L")#> b0 CMAX CMAXD TMAX TLAG CLST #> -1.72421060 1.50000000 0.06000000 0.25000000 NA 0.05000000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 0.05024851 8.00000000 4.37812701 0.15832048 5.00000000 8.00000000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.00000000 -0.99853229 0.99706673 0.99413345 2.39361702 2.04045213 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 2.04045213 2.35626723 0.09425069 2.35783688 0.09431348 13.40319561 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 13.46084419 20.65564214 20.64189142 3.27125000 7.79255448 7.81502594 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 58.02082606 58.14153371 1.60319860 3.30716074 3.31448966 NA #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> NA NA 67.01597804 66.97136466 NA NA #> CLO CLP CLFO CLFP VSSO VSSP #> 10.61000197 10.60293876 NA NA 35.08898193 35.14333088 #> AUC[0-12h] AUC[0-24h] #> 2.18894711 2.33163353 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L" #> [49] "h*mg/L" "h*mg/L"sNCA(Indometh[Indometh$Subject==1,"time"], Indometh[Indometh$Subject==1, "conc"], dose=25, adm="Infusion", dur=0.25, iAUC=iAUC, concUnit="mg/L")#> b0 CMAX CMAXD TMAX TLAG CLST #> -1.72421060 1.50000000 0.06000000 0.25000000 0.00000000 0.05000000 #> CLSTP TLST LAMZHL LAMZ LAMZLL LAMZUL #> 0.05024851 8.00000000 4.37812701 0.15832048 5.00000000 8.00000000 #> LAMZNPT CORRXY R2 R2ADJ C0 AUCLST #> 3.00000000 -0.99853229 0.99706673 0.99413345 NA 1.74125000 #> AUCALL AUCIFO AUCIFOD AUCIFP AUCIFPD AUCPEO #> 1.74125000 2.05706511 0.08228260 2.05863475 0.08234539 15.35270349 #> AUCPEP AUCPBEO AUCPBEP AUMCLST AUMCIFO AUMCIFP #> 15.41724428 NA NA 3.27125000 7.79255448 7.81502594 #> AUMCPEO AUMCPEP MRTIVLST MRTIVIFO MRTIVIFP MRTEVLST #> 58.02082606 58.14153371 1.75367911 3.66319049 3.67121783 NA #> MRTEVIFO MRTEVIFP VZO VZP VZFO VZFP #> NA NA 76.76351746 76.70498779 NA NA #> CLO CLP CLFO CLFP VSSO VSSP #> 12.15323712 12.14397067 NA NA 44.51962266 44.58316170 #> AUC[0-12h] AUC[0-24h] #> 1.88974498 2.03243140 #> attr(,"units") #> [1] "" "mg/L" "mg/L/mg" "h" "h" "mg/L" #> [7] "mg/L" "h" "h" "/h" "h" "h" #> [13] "" "" "" "" "mg/L" "h*mg/L" #> [19] "h*mg/L" "h*mg/L" "h*mg/L/mg" "h*mg/L" "h*mg/L/mg" "%" #> [25] "%" "%" "%" "h2*mg/L" "h2*mg/L" "h2*mg/L" #> [31] "%" "%" "h" "h" "h" "h" #> [37] "h" "h" "L" "L" "L" "L" #> [43] "L/h" "L/h" "L/h" "L/h" "L" "L" #> [49] "h*mg/L" "h*mg/L"