Power using coefficient of variation (CV)

It calculates power for the bioequivalence test on ratio using coefficient of variation (CV).

powcv(n, CV, DesignNo = 1, True.R = 1, Alpha = 0.1, ThetaL = 0.8, ThetaU = 1.25)

Arguments

n

Sample size, n per group

CV

Coefficient of Variation (%)

DesignNo

Crossover design number.

  
 Design Number (treatment x sequence x period)
 1 2x2x2 : RT TR
 2 2x4x2 (Balaam Design) : TT RR RT TR 
 3 2x2x3 (Two-sequence Dual Design): TRR RTT 
 4 2x2x4 : TRRT RTTR
 5 2x4x4 : TTRR RRTT TRRT RTTR
 6 3x6x3 (William Design for 3 treatments) + carry-over effect 
         : RBA ARB BAR ABR BRA RAB
 7 3x6x3 (William Design for 3 treatments) - carry-over effect 
         : RBA ARB BAR ABR BRA RAB
 8 4x4x4 (William Design for 4 treatments) + carry-over effect 
         : RCAB ARBC BACR CBRA
 9 4x4x4 (William Design for 4 treatments) - carry-over effect 
         : RCAB ARBC BACR CBRA 

True.R

True ratio of test/reference

Alpha

Alpha error level

ThetaL

Lower limit of equivalence criteria

ThetaU

Upper limit of equivalence criteria

Details

It calculates power of sample size (n per group) with CV.

Value

Returns power [0, 1)

Author

Kyun-Seop Bae <k@acr.kr>

Examples

powcv(12, 25) 
#> [1] 0.8438499